DotDr is a specialized biomedical AI systems engineering studio that orchestrates frontier Google AI models—including AlphaGenome, AlphaFold2, and MedLM—into high-throughput, sovereign clinical pipelines for South African pathology networks and genetics laboratories.

How does DotDr ensure POPIA compliance in South Africa?

DotDr adheres strictly to Section 19 of South Africa's Protection of Personal Information Act (POPIA). All pipelines ingest exclusively de-identified genomic coordinate tokens (e.g., chr:pos:ref>alt) with zero Personally Identifiable Information (PII). All compute runs within in-country cloud residency (GCP africa-south1 in Johannesburg) or on-premise behind laboratory firewalls.

How does DotDr use AlphaGenome and AlphaFold for diagnostic workflows?

DotDr uses AlphaGenome to triage over 9 billion non-coding variants and score cryptic splice sites, promoter disruptions, and distal enhancers. For coding missense variants, DotDr automates AlphaFold2/ColabFold structural delta-analysis to compute C-alpha RMSD and residue-level pLDDT stability shifts to validate protein destabilization.

What are DotDr's pricing and engagement tiers?

DotDr offers a zero-cost 30-Day Anonymized Pilot Trial (R0) for 20-50 historical variants, a 2-Week Custom AI Production Sprint (R160,000 ZAR), High-Throughput Compute Clusters in GCP Johannesburg, and Managed SLA & Support.

DotDr_

Specialized AI Model Orchestration for South African Pathology Networks, Genetics Laboratories & Research Biobanks.

01. Core AI Pipelines & Capabilities [ SEC_01 ]

We do not replace clinical geneticists or in-house bioinformatics teams. We build and orchestrate custom AI pipelines around your existing diagnostic workflows.

[A] AlphaGenome Triage

Screening 9 billion variants with AlphaGenome Variant Impact (AVI) scores. Filters top 1% causal mutations, promoters, enhancers & cryptic splice sites.

[B] Structural Δ-Analysis

Automated ColabFold / AlphaFold2 modeling. Computes Cα-RMSD, residue ΔpLDDT shifts, and PAE matrices to validate mutant protein destabilization.

[C] Sovereign Clinical LLMs

Converts raw VCF annotations into ACMG-compliant draft clinical summaries. Grounded in literature with human-in-the-loop pathologist review gates.

02. Commercial Pricing Schedule & Architecture Blueprint [ SEC_02 ]

Transparent, predictable pricing designed to de-risk adoption from day one:

Request the Complete Diagnostic AI Pricing & Deployment Guide

Get instant access to our itemized cost schedules, turnaround time benchmarks, and complete cloud architecture specifications sent directly from duncan@dotdr.co.za:

1. Anonymized Pilot Trial (R0) 30-day evaluation on 20–50 historical variants with full comparative report.

2. Custom AI Sprint (R160k ZAR) 2-week fixed production deployment, LIMS / VCF integration & custom agent build.

3. High-Throughput Compute Direct cost-plus GPU cluster pass-through in GCP africa-south1 (Johannesburg).

4. Managed SLA & Support Continuous AlphaGenome database sync, uptime monitoring & model re-weighting.

[+] Request Confirmed & Dispatched

Thank you, . The complete DotDr Commercial Pricing Schedule & Technical Architecture Blueprint has been generated and is being sent to from duncan@dotdr.co.za.

Duncan Luke (Principal AI Systems Specialist) has been notified and will follow up with any specific assay parameters requested.

03. POPIA Compliance & Ethical Guardrails [ SEC_03 ]

POPIA Section 19 Safeguards Analysis runs on de-identified pseudonymous coordinates (e.g. chr9:130714457:G>A). Zero patient-identifiable data is processed or stored.

HPCSA Ethical Alignment Booklet 2 & 10 compliant. AI predictions strictly operate as assistive decision support. Registered pathologists maintain 100% final diagnostic authority.

In-Country Sovereign Cloud Primary compute hosted in GCP africa-south1 (Johannesburg) or on-premise firewall. Zero transmission to public consumer models.

Reproducible Auditability Every score, pLDDT metric, and draft report sentence is version-tagged with reproducible provenance and checkpoint audit logs.

04. Engineering Leadership & Direct Briefing [ SEC_04 ]

DotDr is led by AI systems engineers specializing in frontier Google model orchestration (AlphaGenome, AlphaFold, MedLM) for high-performance South African genomics workflows.

Principal Engineering: Duncan Luke — Lead AI Systems Specialist
Inquiries & Blueprint Dispatch: Automated via the Pricing & Blueprint Form above
Compute Infrastructure: Google Cloud Platform africa-south1 (Johannesburg)

05. Frequently Asked Questions [ SEC_05 ]

What does DotDr do for pathology and genetics laboratories in South Africa?

DotDr builds sovereign, high-throughput AI pipelines that automate Variant of Uncertain Significance (VUS) triage, non-coding impact scoring via AlphaGenome, 3D structural delta-analysis with AlphaFold2, and draft ACMG clinical report synthesis using domain-tuned MedLM architectures.

How does DotDr maintain POPIA and HPCSA compliance?

DotDr operates on a zero-PII architectural paradigm under POPIA Section 19. Genetic pipelines process de-identified coordinate tokens (chr:pos:ref>alt) without linking to patient identifiers. All GPU compute executes within South African data residency (GCP Johannesburg africa-south1) or on-premise behind institutional firewalls.

How can our diagnostic laboratory evaluate DotDr's AI pipelines?

Laboratories can initiate a zero-cost 30-Day Anonymized Pilot Trial (R0) on 20–50 historical genetic variants to benchmark turnaround time, variant classification concordances, and structural destabilization predictions against existing in-house workflows.

Who leads technical architecture and engineering at DotDr?

Engineering is directed by Duncan Luke, Lead AI Systems Specialist, focusing on high-concurrency model orchestration, bioinformatics pipeline acceleration, and sovereign cloud architectures.